immunodeficiency

Diagnostic evaluation of pediatric autoimmune-lymphoproliferative immunodeficiencies (ALPID): A prospective cohort study

Background: Lymphoproliferation and autoimmune cytopenias characterize autoimmune-lymphoproliferative syndrome (ALPS). Other conditions sharing these manifestations have been termed “ALPS-like”, although they are frequently more severe. Insufficient …

Activated Phosphoinositide 3-Kinase δ Syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity

Background Activated phosphoinositide-3-kinase (PI3K) δ Syndrome (APDS) is an inborn error of immunity (IEI) with infection susceptibility and immune dysregulation, clinically overlapping with other conditions. Management depends on disease …